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Article

PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids.

Development (Cambridge, England) - 1 May 2005

Goberdhan Deborah C I, Meredith David, Boyd C A Richard, Wilson Clive

Abstract excerpt

Growth in normal and tumour cells is regulated by evolutionarily conserved extracellular inputs from the endocrine insulin receptor (InR) signalling pathway and by local nutrients. Both signals modulate activity of the intracellular TOR kinase, with nutrients at least partly acting through changes in intracellular amino acid levels mediated by amino acid transporters. We show that in Drosophila, two molecules...

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Source

Identifiers

PMID: 15843412
DOI: 10.1242/dev.01821

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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