Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence for p53 as guardian of the cardiomyocyte mitochondrial genome following acute adriamycin treatment.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society - 1 Jun 2007

Nithipongvanitch Ramaneeya, Ittarat Wanida, Velez Joyce M, Zhao Rui, St Clair Daret K, Oberley Terry D

Abstract excerpt

The present study is an initial analysis of whether p53 may function as guardian of the cardiomyocyte mitochondrial genome, with mitochondrial p53 localization proposed to be involved in both mitochondrial DNA (mtDNA) repair and apoptosis. Subcellular distribution, protein levels, and possible function(s) of p53 protein in the response of cardiomyocytes to adriamycin (ADR) were analyzed. Levels and subcellular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 8-Hydroxy-2'-Deoxyguanosine
Share to bcl-2-Associated X Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochromes c

Share to Deoxyguanosine

Share to Doxorubicin

Share to HCT116 Cells

Share to Microscopy, Immunoelectron

Share to Mitochondria, Heart

Source

Identifiers

PMID: 17312011
DOI: 10.1369/jhc.6A7146.2007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence for p53 as guardian of the cardiomyocyte mitochondrial genome following acute adriamycin treatment.PMID 17312011Read ↗

Doxorubicin-Induced p53 Interferes with Mitophagy in Cardiac FibroblastsSemantic proximity Read ↗

Mitochondrial death functions of p53Semantic proximity Read ↗

The Abl1 tyrosine kinase is a key player in doxorubicin-induced cardiomyopathy and its p53/p73 cell death mediated signaling differs in atrial and ventricular cardiomyocytesSemantic proximity Read ↗

p53 prevents doxorubicin cardiotoxicity independently of its prototypical tumor suppressor activitiesSemantic proximity Read ↗

Watching the Watcher: Regulation of p53 by MitochondriaSemantic proximity Read ↗

Targeted deletion of Puma attenuates cardiomyocyte death and improves cardiac function during ischemia-reperfusionSemantic proximity Read ↗

Transcriptomic profiling reveals p53 as a key regulator of doxorubicin-induced cardiotoxicitySemantic proximity Read ↗

MiR-486 regulates cardiomyocyte apoptosis by p53-mediated BCL-2 associated mitochondrial apoptotic pathwaySemantic proximity Read ↗

Mitochondrial DNA mutations activate programmed cell survival in the mouse heart.Semantic proximity Read ↗

Cell death decision by p53 via control of the mitochondrial membrane.Semantic proximity Read ↗

Mitochondrial DNA mutations, apoptosis, and the misfolded protein response.Semantic proximity Read ↗

Targeting p53 to mitochondria for cancer therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.