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Article

Transgenic overexpression of prothymosin alpha induces development of polycystic kidney disease.

Kidney international - 1 May 2005

Li Kuo-Jung, Shiau Ai-Li, Chiou Yuan-Yow, Yo Yi-Te, Wu Chao-Liang

Abstract excerpt

BACKGROUND: Polycystic kidney disease (PKD) is a genetic disorder characterized by development of renal cysts and progressive renal dysfunction. Renal tissues from both PKD patients and rodent models of PKD show elevated c-myc expression. Prothymosin alpha (ProT) is positively regulated by c-myc through binding to the E box of its promoter. Through creating transgenic mice and clinical studies, we sought to...

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Source

Identifiers

PMID: 15840017
DOI: 10.1111/j.1523-1755.2005.00268.x

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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