Article
Association of a single nucleotide polymorphism in the lipoxygenase ALOX15 5'-flanking region (-5229G/A) with bone mineral density.
Journal of bone and mineral metabolism - 1 Jan 2005
Urano Tomohiko, Shiraki Masataka, Fujita Masayo, Hosoi Takayuki, Orimo Hajime, Ouchi Yasuyoshi, Inoue Satoshi
Abstract excerpt
The 12/15-lipoxygenase gene Alox15 has been identified as a susceptibility gene for bone mineral density (BMD) in mice through combined genetic and genomic analyses. Here we studied the association between bone mineral density and an ALOX15 gene single nucleotide polymorphism to assess the potential involvement of the human ALOX15 gene in postmenopausal osteoporosis. Specifically, we examined the association...
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