Article
Transferred melanoma-specific CD8+ T cells persist, mediate tumor regression, and acquire central memory phenotype.
Proceedings of the National Academy of Sciences of the United States of America - 20 Mar 2012
Chapuis Aude G, Thompson John A, Margolin Kim A, Rodmyre Rebecca, Lai Ivy P, Dowdy Kaye, Farrar Erik A, Bhatia Shailender, Sabath Daniel E, Cao Jianhong, Li Yongqing, Yee Cassian
Abstract excerpt
Adoptively transferred tumor-specific T cells offer the potential for non-cross-resistant therapy and long-term immunoprotection. Strategies to enhance in vivo persistence of transferred T cells can lead to improved antitumor efficacy. However, the extrinsic (patient conditioning) and intrinsic (effector cell) factors contributing to long-term in vivo persistence are not well-defined. As a means to enhance...
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