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Article

Molecular mechanisms for activation of voltage-independent Ca2+ channels by endothelin-1/endothelin-A receptors.

Journal of cardiovascular pharmacology - 1 Nov 2004

Kawanabe Yoshifumi, Okamoto Yasuo, Hashimoto Nobuo, Masaki Tomoh

Abstract excerpt

Endothelin-1 (ET-1) activates two types of Ca2+- permeable non-selective cation channels (designated NSCC-1 and NSCC-2) and a store-operated Ca2+ channel (SOCC) in Chinese hamster ovary cells expressing endothelin-A receptors (CHOETAR), which couple with Gq, Gs and G12. The purpose of this study was to identify the G proteins involved in the activation of these Ca channels, using mutated ETARs with coupling to...

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Identifiers

PMID: 15838284
DOI: 10.1097/01.fjc.0000166252.66486.06

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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