Article
Molecular mechanism for endothelin-1-induced stress-fiber formation: analysis of G proteins using a mutant endothelin(A) receptor.
Molecular pharmacology - 1 Feb 2002
Kawanabe Yoshifumi, Okamoto Yasuo, Nozaki Kazuhiko, Hashimoto Nobuo, Miwa Soichi, Masaki Tomoh
Abstract excerpt
The purposes of the present study were to clarify the significance of the palmitoylation site and the cytoplasmic tail of the endothelin(A) receptor (ET(A)R) in coupling with G proteins and to determine the subtypes of G protein that are involved in actin stress-fiber formation in Chinese hamster ovary cells that stably express ET(A)R (CHO-ET(A)R). For these purposes, we constructed CHO cells stably expressing an...
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