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Article

New strategies for immunosuppression: interfering with cytokines by targeting the Jak/Stat pathway

15 Apr 2005

Abstract excerpt

PURPOSE OF REVIEW: Numerous immunosuppressants are available, but their adverse effects related to actions on nonlymphoid cells is problematic. Cytokines are key regulators of immune and inflammatory responses, and blocking their actions has become an important modality in treating autoimmune disorders. This review will discuss strategies to develop novel immunosuppressants that arise from advances in the...

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PMID: 15838241
DOI: 10.1097/01.bor.0000160781.07174.db

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