Article
JAK3 inhibition as a new concept for immune suppression.
Current opinion in investigational drugs (London, England : 2000) - 1 Nov 2003
Borie Dominic C, Si Ming-Sing, Morris Randall E, Reitz Bruce A, Changelian Paul S
Abstract excerpt
Although current immunosuppressive drugs are effective, they have numerous severe side effects that mandate the search for new agents. Mutations in the gene for janus kinase (JAK)3 result in severe combined immune deficiency with severely impaired humoral and cellular immunity, an observation that has prompted the development of JAK3 inhibitors. Due to its central role in lymphocyte activation, proliferation and...
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