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Article

Therapeutic targeting of Janus kinases.

Immunological reviews - 1 Jun 2008

Pesu Marko, Laurence Arian, Kishore Nandini, Zwillich Samuel H, Chan Gary, O'Shea John J

Abstract excerpt

SUMMARY: Cytokines play pivotal roles in immunity and inflammation, and targeting cytokines and their receptors is an effective means of treating such disorders. Type I and II cytokine receptors associate with Janus family kinases (JAKs) to effect intracellular signaling. These structurally unique protein kinases play essential and specific roles in immune cell development and function. One JAK, JAK3, has...

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Source

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Identifiers

PMID: 18613833
DOI: 10.1111/j.1600-065X.2008.00644.x
PMCID: PMC2634846

Genes

JAK3
JAK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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