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Random Insertional Mutagenesis of<i>Leptospira interrogans</i>, the Agent of Leptospirosis, Using a<i>mariner</i>Transposon

18 Apr 2005

Abstract excerpt

The recent availability of the complete genome sequences of Leptospira interrogans, the agent of leptospirosis, has allowed the identification of several putative virulence factors. However, to our knowledge, attempts to carry out gene transfer in pathogenic Leptospira spp. have failed so far. In this study, we show that the Himar1 mariner transposon permits random mutagenesis in the pathogen L. interrogans. We...

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PMID: 15838053
DOI: 10.1128/jb.187.9.3255-3258.2005

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