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Article

Nucleus pulposus cells upregulate PI3K/Akt and MEK/ERK signaling pathways under hypoxic conditions and resist apoptosis induced by serum withdrawal.

Spine - 15 Apr 2005

Risbud Makarand V, Fertala Jolanta, Vresilovic Edward J, Albert Todd J, Shapiro Irving M

Abstract excerpt

STUDY DESIGN: To examine the impact of hypoxia, rat nucleus pulposus cells were maintained in monolayer culture in 2% O2 and survival and signal transduction pathways identified. OBJECTIVE: To elucidate the signaling pathways that allow nucleus pulposus cells to adapt to low oxygen environment. SUMMARY OF BACKGROUND DATA: Mammalian cell function is critically dependent on a continuous supply of oxygen....

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PMID: 15834331
DOI: 10.1097/01.brs.0000159096.11248.6d

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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