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Hypoxia‑inducible factor‑1α regulates PI3K/AKT signaling through microRNA‑32‑5p/PTEN and affects nucleus pulposus cell proliferation and apoptosis

18 Apr 2021

Abstract excerpt

Intervertebral disc degeneration and resulting low back pain arises from the programmed apoptosis of nucleus pulposus cells (NPCs). Recent studies show that hypoxia‑inducible factor‑1α plays a vital role in the etiology and pathogenesis of disc degeneration. However, the underlying mechanism of HIF‑1α in NPCs is unclear. The present study identified 994 significant differentially expressed miRNAs by analyzing...

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PMID: 33968177
DOI: 10.3892/etm.2021.10078

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