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Article

Differentiation of mesenchymal stem cells towards a nucleus pulposus-like phenotype in vitro: implications for cell-based transplantation therapy.

Spine - 1 Dec 2004

Risbud Makarand V, Albert Todd J, Guttapalli Asha, Vresilovic Edward J, Hillibrand Alan S, Vaccaro Alexander R, Shapiro Irving M

Abstract excerpt

OBJECTIVE: Because mesenchymal stem cells can differentiate into chondrocyte-like cells, we ask the question, can mesenchymal stem cells commit to the nucleus pulposus phenotype? BACKGROUND: Back pain, a significant source of morbidity in our society, is linked to degenerative changes of the intervertebral disc. Absence of suitable graft tissue limits therapeutic approaches for repair of disc tissue. For this...

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Source

Identifiers

PMID: 15564911
DOI: 10.1097/01.brs.0000146462.92171.7f

Genes

ALCAM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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