Article
EGR1 controls divergent cellular responses of distinctive nucleus pulposus cell types.
BMC musculoskeletal disorders - 14 Mar 2016
van den Akker Guus G H, Surtel Don A M, Cremers Andy, Hoes Martijn F G A, Caron Marjolein M, Richardson Stephen M, Rodrigues-Pinto Ricardo, van Rhijn Lodewijk W, Hoyland Judith A, Welting Tim J M, Voncken Jan Willem
Abstract excerpt
BACKGROUND: Immediate early genes (IEGs) encode transcription factors which serve as first line response modules to altered conditions and mediate appropriate cell responses. The immediate early response gene EGR1 is involved in physiological adaptation of numerous different cell types. We have previously shown a role for EGR1 in controlling processes supporting chondrogenic differentiation. We recently...
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