Prediction of phenotype and gene expression for combinations of mutations.

doi:10.1038/msb4100137

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Article

Prediction of phenotype and gene expression for combinations of mutations.

Molecular systems biology - 1 Jan 2007

Carter Gregory W, Prinz Susanne, Neou Christine, Shelby J Patrick, Marzolf Bruz, Thorsson Vesteinn, Galitski Timothy

Abstract excerpt

Molecular interactions provide paths for information flows. Genetic interactions reveal active information flows and reflect their functional consequences. We integrated these complementary data types to model the transcription network controlling cell differentiation in yeast. Genetic interactions were inferred from linear decomposition of gene expression data and were used to direct the construction of a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17389876
DOI: 10.1038/msb4100137
PMCID: PMC1847951

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.