Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Implication of allelic polymorphism of osteopontin in the development of lupus nephritis in MRL/lpr mice.

European journal of immunology - 1 May 2005

Miyazaki Tatsuhiko, Ono Masao, Qu Wei-Min, Zhang Ming-Cai, Mori Shiro, Nakatsuru Shuichi, Nakamura Yusuke, Sawasaki Tatsuya, Endo Yaeta, Nose Masato

Abstract excerpt

Potentially, autoimmune diseases develop from a combination of multiple genes with allelic polymorphisms. An MRL/Mp-Fas(lpr) (/) (lpr) (MRL/lpr) strain of mice develops autoimmune diseases, including lupus nephritis, but another lpr strain, C3H/HeJ-Fas(lpr) (/) (lpr) (C3H/lpr) does not. This indicates that MRL polymorphic genes are involved in the development of the diseases. By quantitative trait loci (QTL)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Lod Score
Share to Lupus Erythematosus, Systemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lupus Nephritis

Share to Lymphocyte Activation

Share to Mice, Inbred C3H

Share to Mice, Inbred MRL lpr

Share to Osteopontin

Share to Sialoglycoproteins

Source

Identifiers

PMID: 15832294
DOI: 10.1002/eji.200425672

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Implication of allelic polymorphism of osteopontin in the development of lupus nephritis in MRL/lpr mice.PMID 15832294Read ↗

Arthritis in MRL/lpr mice is under the control of multiple gene loci with an allelic combination derived from the original inbred strains.Semantic proximity Read ↗

Genetic dissection of the complex pathological manifestations of collagen disease in MRL/lpr mice.Semantic proximity Read ↗

Vasculitis-susceptible genes in mice with a deficit in Fas-mediated apoptosis.Semantic proximity Read ↗

Genetic heterogeneity in rheumatoid arthritis mouse models induced by extrinsic and intrinsic factors.Semantic proximity Read ↗

Genetic dissection of vasculitis in MRL/lpr lupus mice: a novel susceptibility locus involving the CD72c allele.Semantic proximity Read ↗

Genetic basis of the complex pathological manifestations of collagen disease: lessons from MRL/lpr and related mouse models.Semantic proximity Read ↗

Genetic basis of autoimmune disease in MRL/lpr mice: dissection of the complex pathological manifestations and their susceptibility loci.Semantic proximity Read ↗

Autosomal loci associated with a sex-related difference in the development of autoimmune phenotypes in a lupus model.Semantic proximity Read ↗

Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci.Semantic proximity Read ↗

Genetic characterisation of spontaneous ankylosing arthropathy with unique inheritance from Fas-deficient strains of mice.Semantic proximity Read ↗

Differential roles of osteopontin/Eta-1 in early and late lpr disease.Semantic proximity Read ↗

Non-MHC-linked genes in autoimmune diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.