Article
Non-MHC-linked genes in autoimmune diseases.
Current opinion in immunology - 1 Dec 1992
Garchon H J
Abstract excerpt
The gene responsible for the lpr mutation in MRL mice that are prone to systemic lupus erythematosus has been shown to encode the apoptosis-inducing Fas antigen, thus pointing to control of apoptosis as a major regulatory mechanism in autoimmunity. In the non-obese diabetic mouse model for insulin-dependent diabetes, four non-MHC-linked loci have been localized in the murine genome that were found to be...
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