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Article

Preferential development of CD4 and CD8 T regulatory cells in RasGRP1-deficient mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2008

Chen Xiaoxi, Priatel John J, Chow Michael T, Teh Hung-Sia

Abstract excerpt

RasGRP1 and Sos are two Ras-guanyl-nucleotide exchange factors that link TCR signal transduction to Ras and MAPK activation. Recent studies demonstrate positive selection of developing thymocytes is crucially dependent on RasGRP1, whereas negative selection of autoreactive thymocytes appears to be RasGRP1 independent. However, the role of RasGRP1 in T regulatory (Treg) cell development and function is unknown. In...

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Source

Identifiers

PMID: 18424717
DOI: 10.4049/jimmunol.180.9.5973

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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