Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RasGRP1 sensitizes an immature B cell line to antigen receptor-induced apoptosis.

The Journal of biological chemistry - 7 May 2004

Guilbault Benoit, Kay Robert J

Abstract excerpt

RasGRP1 is a guanine nucleotide exchange factor that activates Ras GTPases and is activated downstream of antigen receptors on both T and B lymphocytes. Ras-GRP1 provides signals to immature T cells that confer survival and proliferation, but RasGRP1 also promotes T cell receptor-mediated deletio...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to bcl-X Protein
Share to Guanine Nucleotide Exchange Factors
Share to Guanosine Triphosphate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin M

Share to Mitogen-Activated Protein Kinase 1

Share to Mitogen-Activated Protein Kinase 3

Share to Retroviridae

Share to Trypsin

Source

Identifiers

PMID: 14970203
DOI: 10.1074/jbc.M314273200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14970203-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RasGRP1 sensitizes an immature B cell line to antigen receptor-induced apoptosis.PMID 14970203Read ↗

Deregulated expression of RasGRP1 initiates thymic lymphomagenesis independently of T-cell receptors.Semantic proximity Read ↗

Loss of RASGRP1 in humans impairs T-cell expansion leading to Epstein-Barr virus susceptibility.Semantic proximity Read ↗

Heterotrimeric G Proteins and Apoptosis: Intersecting Signaling Pathways Leading to Context Dependent PhenotypesSemantic proximity Read ↗

Aberrant expression of RasGRP1 cooperates with gain-of-function NOTCH1 mutations in T-cell leukemogenesis.Semantic proximity Read ↗

Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas.Semantic proximity Read ↗

Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction.Semantic proximity Read ↗

Rapid B cell receptor-induced unfolded protein response in nonsecretory B cells correlates with pro- versus antiapoptotic cell fate.Semantic proximity Read ↗

NF kappa B controls the balance between Fas and tumor necrosis factor cell death pathways during T cell receptor-induced apoptosis via the expression of its target gene A20.Semantic proximity Read ↗

Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor.Semantic proximity Read ↗

Dissection of pathways leading to antigen receptor-induced and Fas/CD95-induced apoptosis in human B cells.Semantic proximity Read ↗

Activation or suppression of NFkappaB by HPK1 determines sensitivity to activation-induced cell death.Semantic proximity Read ↗

Apoptosis induced by Rac GTPase correlates with induction of FasL and ceramides production.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.