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Article

Ets2-dependent trophoblast signalling is required for gastrulation progression after primitive streak initiation.

Nature communications - 1 Jan 2013

Polydorou Christiana, Georgiades Pantelis

Abstract excerpt

Although extraembryonic ectoderm trophoblast signals the embryo for primitive streak initiation, a prerequisite for gastrulation, it is unknown whether it also signals for the progression of gastrulation after primitive streak initiation. Here, using Ets2-/- mice, we show that trophoblast signalling is also required in vivo for primitive streak elongation, completion of intraembryonic mesoderm...

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Identifiers

PMID: 23552073
DOI: 10.1038/ncomms2646

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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