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Article

Phytoestrogen exposure elevates PTEN levels

13 Apr 2005

Abstract excerpt

Epidemiological data suggest that consumption of phytoestrogens can be protective against the development of breast cancer. It may be logical to postulate that phytoestrogens may regulate proteins that control cellular division, such as the tumor suppressor PTEN. Germline, and more significantly, somatic PTEN mutations have been observed in a broad range of human cancers, especially those of the breast. Active...

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Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 15829497
DOI: 10.1093/hmg/ddi155

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Related research

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Research trail→

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Phytoestrogen exposure elevates PTEN levelsPMID 15829497Read ↗

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PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1.Semantic proximity Read ↗

The effects of the tumor suppressor gene PTEN on the proliferation and apoptosis of breast cancer cells via AKT phosphorylationSemantic proximity Read ↗

Cell cycle arrest by the PTEN tumor suppressor is target cell specific and may require protein phosphatase activity.Semantic proximity Read ↗

Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells.Semantic proximity Read ↗

Increased PTEN expression due to transcriptional activation of PPARgamma by Lovastatin and Rosiglitazone.Semantic proximity Read ↗

The role of early life genistein exposures in modifying breast cancer risk.Semantic proximity Read ↗

Growth suppression activity of the PTEN tumor suppressor gene in human endometrial cancer cells.Semantic proximity Read ↗

Role of PTEN in Oxidative Stress and DNA Damage in the Liver of Whole-Body Pten Haplodeficient MiceSemantic proximity Read ↗

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