Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deletion of PTEN Promotes Tumorigenic Signaling, Resistance to Anoikis, and Altered Response to Chemotherapeutic Agents in Human Mammary Epithelial Cells

20 Oct 2009

Abstract excerpt

Many cancers, including breast cancer, harbor loss-of-function mutations in the catalytic domain of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) or have reduced PTEN expression through loss of heterozygosity and/or epigenetic silencing mechanisms. However, specific phenotypic effects of PTEN inactivation in human cancer cells remain poorly defined without a direct causal connection between the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to PI3K/AKT/mTOR signaling in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19843859
DOI: 10.1158/0008-5472.can-09-1067

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deletion of PTEN Promotes Tumorigenic Signaling, Resistance to Anoikis, and Altered Response to Chemotherapeutic Agents in Human Mammary Epithelial CellsPMID 19843859Read ↗

Therapeutic targeting of cancers with loss of PTEN function.Semantic proximity Read ↗

Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosisSemantic proximity Read ↗

The biology and clinical relevance of the PTEN tumor suppressor pathway.Semantic proximity Read ↗

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer.Semantic proximity Read ↗

Decoding PTEN: from biological functions to signaling pathways in tumors.Semantic proximity Read ↗

Tenets of PTEN tumor suppression.Semantic proximity Read ↗

The regulation of PTEN: Novel insights into functions as cancer biomarkers and therapeutic targetsSemantic proximity Read ↗

The Mechanisms Underlying PTEN Loss in Human Tumors Suggest Potential Therapeutic Opportunities.Semantic proximity Read ↗

PTEN: Multiple Functions in Human Malignant TumorsSemantic proximity Read ↗

The PTEN tumor suppressor gene and its role in lymphoma pathogenesis.Semantic proximity Read ↗

Partial PTEN deletion is linked to poor prognosis in breast cancerSemantic proximity Read ↗

The functions and regulation of the PTEN tumour suppressor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.