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Article

Increased PTEN expression due to transcriptional activation of PPARgamma by Lovastatin and Rosiglitazone.

International journal of cancer - 15 May 2006

Teresi Rosemary E, Shaiu Chung-Wai, Chen Ching-Shih, Chatterjee V Krishna, Waite Kristin A, Eng Charis

Abstract excerpt

Germline mutations in the tumor suppressor gene PTEN (protein phosphatase and tensin homolog located on chromosome ten) predispose to heritable breast cancer. The transcription factor PPARgamma has also been implicated as a tumor suppressor pertinent to a range of neoplasias, including breast cancer. A putative PPARgamma binding site in the PTEN promoter indicates that PPARgamma may regulate PTEN expression. We...

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Source

Identifiers

PMID: 16425225
DOI: 10.1002/ijc.21799

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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