Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PTEN regulates phospholipase D and phospholipase C.

Human molecular genetics - 15 May 2007

Alvarez-Breckenridge Christopher A, Waite Kristin A, Eng Charis

Abstract excerpt

PTEN is an ubiquitously expressed tumor suppressor which plays a prominent role in the pathogenesis of many types of sporadic solid tumors, including breast cancer, as well as hematologic malignancies. Germline PTEN mutations cause 85% of Cowden syndrome (CS), characterized by a high risk of breast and thyroid cancers, and 65% of Bannayan-Riley-Ruvalcaba syndrome (BRRS), characterized by lipomatosis, hemangiomas...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Estradiol
Share to Homeostasis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Phospholipase C gamma

Share to Phospholipase D

Share to Phospholipids

Share to PTEN Phosphohydrolase

Share to Type C Phospholipases

Source

Identifiers

PMID: 17405772
DOI: 10.1093/hmg/ddm063

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PTEN regulates phospholipase D and phospholipase C.PMID 17405772Read ↗

PTEN hamartoma tumor syndromes.Semantic proximity Read ↗

PTENSemantic proximity Read ↗

The biology and clinical relevance of the PTEN tumor suppressor pathway.Semantic proximity Read ↗

PTEN and Myotubularin: Novel Phosphoinositide PhosphatasesSemantic proximity Read ↗

PTEN: Multiple Functions in Human Malignant TumorsSemantic proximity Read ↗

PTEN: tumour suppressor, multifunctional growth regulator and more.Semantic proximity Read ↗

PTEN hamartoma tumor syndrome: clinical risk assessment and management protocol.Semantic proximity Read ↗

The role of genetic abnormalities of PTEN and the phosphatidylinositol 3-kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapy.Semantic proximity Read ↗

The PTEN-PI3K Axis in CancerSemantic proximity Read ↗

PTEN and the PI3-kinase pathway in cancer.Semantic proximity Read ↗

The regulation of PTEN: Novel insights into functions as cancer biomarkers and therapeutic targetsSemantic proximity Read ↗

Role of PTEN, a lipid phosphatase upstream effector of protein kinase B, in epithelial thyroid carcinogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.