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Transcriptome-wide analysis of PGC-1α–binding RNAs identifies genes linked to glucagon metabolic action

26 Aug 2020

Abstract excerpt

Significance Glucagon action in liver is a central response to fasting and type 2 diabetes. Glucagon action has been delineated through regulatory mechanisms involving signaling, transcription factor/coactivator-based gluconeogenic gene expression, and metabolic enzyme activity. Understanding the molecular mechanisms whereby glucagon controls energy metabolism will define new strategies and potential therapies to...

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PMID: 32848060
DOI: 10.1073/pnas.2000643117

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