Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional analyses of the mutation nt-128 T→G in the hepatocyte nuclear factor-1α promoter region in Chinese diabetes pedigrees.

Diabetic medicine : a journal of the British Diabetic Association - 1 Nov 2012

Fang Q, Chen S, Wang Y, Jiang S, Zhang R, Hu C, Wang C, Liu F, Xiang K, Jia W

Abstract excerpt

AIMS: Hepatocyte nuclear factor-1α (HNF-1α) regulates the expression of genes encoding proteins involved in glucose metabolism and insulin secretion. Mutations in the HNF-1α gene cause maturity-onset diabetes of the young Type 3. However, the mechanism leading to this disease has not been completely ascertained. Previously, we found a novel mutation in the regulatory element of the human HNF-1α gene in two...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Asian People

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Blotting, Western

Share to Hepatocyte Nuclear Factor 1-alpha

Share to Insulin

Share to Luciferases

Share to Promoter Regions, Genetic

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 22413961
DOI: 10.1111/j.1464-5491.2012.03626.x
PMCID: PMC3570122

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional analyses of the mutation nt-128 T→G in the hepatocyte nuclear factor-1α promoter region in Chinese diabetes pedigrees.PMID 22413961Read ↗

Three new mutations in the hepatocyte nuclear factor-1alpha gene in Japanese subjects with diabetes mellitus: clinical features and functional characterization.Semantic proximity Read ↗

Differential effects of HNF-1α mutations associated with familial young-onset diabetes on target gene regulation.Semantic proximity Read ↗

Effect of mutation at c.493T>C locus of transcription factor HNF1α gene on its protein level.Semantic proximity Read ↗

Mutations in hepatocyte nuclear factor 4alpha (HNF4alpha) gene associated with diabetes result in greater loss of HNF4alpha function in pancreatic beta-cells than in nonpancreatic beta-cells and in reduced activation of the apolipoprotein CIII promoter in hepatic cells.Semantic proximity Read ↗

Identification of four novel mutations in the HNF-1A gene in Chinese early-onset and/or multiplex diabetes pedigrees.Semantic proximity Read ↗

Functional characterization of HNF4A gene variants identify promoter and cell line specific transactivation effects.Semantic proximity Read ↗

Genetic variants of hepatocyte nuclear factor-1beta in Chinese young-onset diabetic patients with nephropathy.Semantic proximity Read ↗

Functional Analyses of HNF1A-MODY Variants Refine the Interpretation of Identified Sequence Variants.Semantic proximity Read ↗

Naturally occurring mutations in the human HNF4alpha gene impair the function of the transcription factor to a varying degreeSemantic proximity Read ↗

Comparative genomic analysis of the HNF-4alpha transcription factor gene.Semantic proximity Read ↗

Analysis of the HNF4 alpha gene in Caucasian type II diabetic nephropathic patients.Semantic proximity Read ↗

A novel mutation in the hepatocyte nuclear factor-1alpha/MODY3 gene in Chinese subjects with early-onset Type 2 diabetes mellitus in Taiwan.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.