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Article

Combination of ganciclovir and trifluridine prevents drug-resistance emergence in HSV-1.

Antimicrobial agents and chemotherapy - 2 May 2024

Schalkwijk Hanna Helena, Shewakramani Neesha Rajesh, Das Kalyan, Andrei Graciela, Snoeck Robert

Abstract excerpt

Ocular herpes simplex virus 1 (HSV-1) infections can lead to visual impairment. Long-term acyclovir (ACV) prophylaxis reduces the frequency of recurrences but is associated with drug resistance. Novel therapies are needed to treat drug-resistant HSV-1 infections. Here, we describe the effects of trifluridine (TFT) in combination with ACV or ganciclovir (GCV) on HSV-1 replication and drug-resistance emergence....

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Source

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Identifiers

PMID: 38619252
DOI: 10.1128/aac.00110-24
PMCID: PMC11064611

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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