Article
Characterization of a spontaneous drug-resistant mutant of monkey B virus (Macacine herpesvirus 1).
Archives of virology - 1 Jan 2009
Black Darla H, Maxwell Lara K, Eberle R
Abstract excerpt
Monkey B virus (Macacine herpesvirus 1; BV) is an alpha-herpesvirus of macaques that causes serious infections in humans. A spontaneous mutant resistant to penciclovir (PCV) was isolated. Several genes were sequenced to identify mutations potentially responsible for PCV resistance. A single nucleotide deletion in the thymidine kinase (TK) gene was identified. To confirm its role in PCV resistance, several TK...
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