Article
Genetic analysis of the role of G protein-coupled receptor signaling in electrotaxis.
The Journal of cell biology - 10 Jun 2002
Zhao Min, Jin Tian, McCaig Colin D, Forrester John V, Devreotes Peter N
Abstract excerpt
Cells display chemotaxis and electrotaxis by migrating directionally in gradients of specific chemicals or electrical potential. Chemotaxis in Dictyostelium discoideum is mediated by G protein-coupled receptors. The unique Gbeta is essential for all chemotactic responses, although different chemoattractants use different receptors and Galpha subunits. Dictyostelium amoebae show striking electrotaxis in an applied...
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