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Article

Recognition of single nucleotide polymorphisms using scanning potential hairpin denaturation.

Journal of the American Chemical Society - 20 Apr 2005

Wei Fang, Chen Chunlai, Zhai Lin, Zhang Ning, Zhao Xin Sheng

Abstract excerpt

Conventional single nucleotide polymorphism (SNP) assays, which based their detection on the stringency or temperature of the washing buffers, have encountered difficulties to distinguish a single base pair mismatch from a perfect match. In this study, scanning potential hairpin denaturation (SPHD) has been developed to detect SNP in a sensitive and reliable manner. Combined with hairpin oligonucleotide probes,...

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Identifiers

PMID: 15826153
DOI: 10.1021/ja043661v

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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