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Article

Rapid determination of single base mismatch mutations in DNA hybrids by direct electric field control.

Proceedings of the National Academy of Sciences of the United States of America - 18 Feb 1997

Sosnowski R G, Tu E, Butler W F, O'Connell J P, Heller M J

Abstract excerpt

We have demonstrated that controlled electric fields can be used to regulate transport, concentration, hybridization, and denaturation of single- and double-stranded oligonucleotides. Discrimination among oligonucleotide hybrids with widely varying binding strengths may be attained by simple adjustment of the electric field strength. When this approach is used, electric field denaturation control allows single...

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Identifiers

PMID: 9037016
DOI: 10.1073/pnas.94.4.1119
PMCID: PMC19754

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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