Article
Structure-specific DNA cleavage on surfaces.
Journal of the American Chemical Society - 10 Jul 2002
Lu Manchun, Hall Jeff G, Shortreed Michael R, Wang Liman, Berggren W Travis, Stevens Priscilla Wilkins, Kelso David M, Lyamichev Victor, Neri Bruce, Skinner James L, Smith Lloyd M
Abstract excerpt
The structure-specific invasive cleavage reaction is a useful means for sensitive and specific detection of single nucleotide polymorphisms, or SNPs, directly from genomic DNA without a need for prior target amplification. A new approach integrating this invasive cleavage assay and surface DNA array technology has been developed for potentially large-scale SNP scoring in a parallel format. Two surface invasive...
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