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Article

Mutation screening based on the mechanical properties of DNA molecules tethered to a solid surface.

The journal of physical chemistry. B - 21 Jan 2010

Yeri Ashish S, Gao Lizeng, Gao Di

Abstract excerpt

We report a rapid gene mutation screening method by making use of the mechanical properties of single-strand DNA (ssDNA) tethered to a solid surface. With proper temperature control, ssDNA in solution undergoes intrabase pairing and forms a specific complex 3D structure. By tethering such ssDNA strands to a solid surface, a DNA film can be formed. The mechanical properties of such DNA films, probed by devices...

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Identifiers

PMID: 20030306
DOI: 10.1021/jp909501h
PMCID: PMC2806934

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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