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Article

Mutation screening based on the mechanical properties of DNA molecules tethered to a solid surface.

The journal of physical chemistry. B - 21 Jan 2010

Yeri Ashish S, Gao Lizeng, Gao Di

Abstract excerpt

We report a rapid gene mutation screening method by making use of the mechanical properties of single-strand DNA (ssDNA) tethered to a solid surface. With proper temperature control, ssDNA in solution undergoes intrabase pairing and forms a specific complex 3D structure. By tethering such ssDNA s...

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Identifiers

PMID: 20030306
DOI: 10.1021/jp909501h
PMCID: PMC2806934

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20030306-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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