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Article

An electrochemical sensor for single nucleotide polymorphism detection in serum based on a triple-stem DNA probe.

Journal of the American Chemical Society - 28 Oct 2009

Xiao Yi, Lou Xinhui, Uzawa Takanori, Plakos Kory J I, Plaxco Kevin W, Soh H Tom

Abstract excerpt

We report here an electrochemical approach that offers, for the first time, single-step, room-temperature single nucleotide polymorphism (SNP) detection directly in complex samples (such as blood serum) without the need for target modification, postwashing, or the addition of exogenous reagents. This sensor, which is sensitive, stable, and reusable, is comprised of a single, self-complementary, methylene...

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PMID: 19807078
DOI: 10.1021/ja905068s
PMCID: PMC2783950

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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