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Article

B lymphocytes undergo TLR2-dependent apoptosis upon Shigella infection.

The Journal of experimental medicine - 2 Jun 2014

Nothelfer Katharina, Arena Ellen T, Pinaud Laurie, Neunlist Michel, Mozeleski Brian, Belotserkovsky Ilia, Parsot Claude, Dinadayala Premkumar, Burger-Kentischer Anke, Raqib Rubhana, Sansonetti Philippe J, Phalipon Armelle

Abstract excerpt

Antibody-mediated immunity to Shigella, the causative agent of bacillary dysentery, requires several episodes of infection to get primed and is short-lasting, suggesting that the B cell response is functionally impaired. We show that upon ex vivo infection of human colonic tissue, invasive S. flexneri interacts with and occasionally invades B lymphocytes. The induction of a type three secretion apparatus...

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Share to Antigens, Bacterial
Share to Apoptosis Regulatory Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dysentery, Bacillary

Share to Microscopy, Confocal

Share to NIH 3T3 Cells

Share to Shigella flexneri

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Source

Open in PubMed Open full text

Identifiers

PMID: 24863068
DOI: 10.1084/jem.20130914
PMCID: PMC4042640

Genes

TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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