Article
No Evidence for BRAF as a melanoma/nevus susceptibility gene.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Apr 2005
Jackson Sharon, Harland Mark, Turner Faye, Taylor Claire, Chambers Philip A, Randerson-Moor Juliette, Swerdlow Anthony J, dos Santos Silva Isabel, Beswick Samantha, Bishop D Timothy, Newton Bishop Julia A
Abstract excerpt
Somatic mutations of BRAF have been identified in both melanoma tumors and benign nevi. Germ line mutations in BRAF have not been identified as causal in families predisposed to melanoma. However, a recent study suggested that a BRAF haplotype was associated with risk of sporadic melanoma in men. Polymorphisms or other variants in the BRAF gene may therefore act as candidate low-penetrance genes for...
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