Article
BRAF polymorphisms and risk of melanocytic neoplasia.
The Journal of investigative dermatology - 1 Dec 2005
James Michael R, Roth Richard B, Shi Michael M, Kammerer Stefan, Nelson Matthew R, Stark Mitchell S, Dumenil Troy, Montgomery Grant W, Hayward Nicholas K, Martin Nicholas G, Braun Andreas, Duffy David L
Abstract excerpt
Somatic mutations of the BRAF gene are common in melanomas and nevi but the contribution of polymorphisms in this gene to melanoma or nevus susceptibility remains unclear. An Australian melanoma case-control sample was typed for 16 single nucleotide polymorphisms (SNP) within the BRAF gene, and five SNP in three neighboring genes. The sample comprised 755 melanoma cases from 740 families stratified by family...
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