Article
An assessment of the CDKN2A variant Ala148Thr as a nevus/melanoma susceptibility allele.
The Journal of investigative dermatology - 1 Oct 2002
Bertram Chandra G, Gaut Rupert M, Barrett Jennifer H, Pinney Elizabeth, Whitaker Linda, Turner Faye, Bataille Veronique, Dos Santos Silva Isabel, J Swerdlow Anthony, Bishop D Timothy, Newton Bishop Julia A
Abstract excerpt
Melanocytic nevi are the most potent risk factors for melanoma yet identified. Variation in the nevus phenotype within a population is predominantly genetically determined. Genes that determine nevus expression may therefore act as low penetrance melanoma susceptibility genes. Rare germline mutations in CDKN2A predispose to melanoma and appear to be nevogenic, although the correlation between nevus phenotype and...
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