BRAF gene is somatically mutated but does not make a major contribution to malignant melanoma susceptibility: the Italian Melanoma Intergroup Study.

doi:10.1200/JCO.2004.07.112

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

BRAF gene is somatically mutated but does not make a major contribution to malignant melanoma susceptibility: the Italian Melanoma Intergroup Study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 15 Jan 2004

Casula Milena, Colombino Maria, Satta Maria P, Cossu Antonio, Ascierto Paolo A, Bianchi-Scarrà Giovanna, Castiglia Daniele, Budroni Mario, Rozzo Carla, Manca Antonella, Lissia Amelia, Carboni Annangela, Petretto Elisabetta, Satriano Sabrina M R, Botti Gerardo, Mantelli Michela, Ghiorzo Paola, Stratton Michael R, Tanda Francesco, Palmieri Giuseppe

Abstract excerpt

PURPOSE: Ocogenic activation of the BRAF gene has been demonstrated to be involved in the pathogenesis of malignant melanoma (MM). In this study, we investigated the contribution of BRAF to melanoma susceptibility, also making a comparison with frequency of CDKN2A germline mutations in MM patients from different areas in Italy. PATIENTS AND METHODS: sing a combination of denaturing high-performance liquid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Neoplasm

Share to Germ-Line Mutation

Share to Italy

Share to Melanoma

Share to Proto-Oncogene Proteins B-raf

Share to Proto-Oncogene Proteins c-raf

Share to Skin Neoplasms

Source

Open in PubMed

Identifiers

PMID: 14722037
DOI: 10.1200/JCO.2004.07.112

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BRAF gene is somatically mutated but does not make a major contribution to malignant melanoma susceptibility: the Italian Melanoma Intergroup Study.PMID 14722037Read ↗

Dissecting the Spectrum of Rare BRAF Mutations in Melanoma: A Nation-Wide Study by the Italian Melanoma Intergroup (IMI).Semantic proximity Read ↗

Exclusion of BRAFV599E as a melanoma susceptibility mutation.Semantic proximity Read ↗

BRAF V600E Mutation in Malignant Melanoma-A Romanian Research Experience.Semantic proximity Read ↗

The \textit{BRAF} V600E mutation in single- institution study of Russian melanoma patients.Semantic proximity Read ↗

Rapid screening of 4000 individuals for germ-line variations in the BRAF gene.Semantic proximity Read ↗

The next generation of metastatic melanoma: uncovering the genetic variants for anti-BRAF therapy response.Semantic proximity Read ↗

Variables that influence BRAF mutation probability: A next-generation sequencing, non-interventional investigation of BRAFV600 mutation status in melanoma.Semantic proximity Read ↗

Prevalence of variations in melanoma susceptibility genes among Slovenian melanoma families.Semantic proximity Read ↗

Rare BRAF mutations in melanoma patients: implications for molecular testing in clinical practice.Semantic proximity Read ↗

Heterogeneous distribution of BRAF/NRAS mutations among Italian patients with advanced melanoma.Semantic proximity Read ↗

Population-based analysis of the prevalence of BRAF mutation in patients diagnosed with cutaneous melanoma and its significance as a prognostic factor.Semantic proximity Read ↗

[BRAF mutation evolution in melanoma: Myth or reality?]Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.