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Mitochondrial DNA Ligases of Trypanosoma brucei

1 Apr 2005

Abstract excerpt

The mitochondrial DNA of Trypanosoma brucei, termed kinetoplast DNA or kDNA, consists of thousands of minicircles and a small number of maxicircles catenated into a single network organized as a nucleoprotein disk at the base of the flagellum. Minicircles are replicated free of the network but still contain nicks and gaps after rejoining to the network. Covalent closure of remaining discontinuities in newly...

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PMID: 15821136
DOI: 10.1128/ec.4.4.765-774.2005

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