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Article

Disruption of the Crithidia fasciculata KAP1 gene results in structural rearrangement of the kinetoplast disc.

Molecular and biochemical parasitology - 1 Oct 2001

Lukes J, Hines J C, Evans C J, Avliyakulov N K, Prabhu V P, Chen J, Ray D S

Abstract excerpt

The mitochondrial DNA (kinetoplast DNA) in trypanosomatids exists as a highly organized nucleoprotein structure with the DNA consisting of thousands of interlocked circles. Four H1 histone-like proteins (KAP1, 2, 3 and 4) are associated with the kinetoplast DNA in the trypanosomatid Crithidia fasciculata. We have disrupted both alleles of the KAP1 gene in this diploid protozoan and shown that expression of the...

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PMID: 11606228
DOI: 10.1016/s0166-6851(01)00348-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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