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Article

Mouse splice mutant generation from ENU-treated ES cells--a gene-driven approach.

Genomics - 1 May 2005

Greber Boris, Lehrach Hans, Himmelbauer Heinz

Abstract excerpt

Mutant mice are important for elucidating mammalian gene functions and for modeling human disease phenotypes. In recent years, chemical mutagenesis has become an increasingly popular method to disrupt gene functions due to its high efficiency of inducing mutations throughout the genome. Mutagenesis of embryonic stem (ES) cells offers the possibility of gene-driven approaches, which, however, require efficient...

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PMID: 15820307
DOI: 10.1016/j.ygeno.2005.01.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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