Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation analysis of candidate genes within the 2q33.3 linkage area for familial early-onset generalised osteoarthritis.

European journal of human genetics : EJHG - 1 Jul 2007

Min Josine L, Meulenbelt Ingrid, Kloppenburg Margreet, van Duijn Cornelia M, Slagboom P Eline

Abstract excerpt

In a genome-wide linkage scan of seven families with familial early-onset osteoarthritis (FOA), we mapped a FOA locus to a 5 cM region on chromosome 2q33.3-2q34 with a maximum LOD score of 6.05. To identify causal variants, 17 positional candidate genes and FRZB were sequenced for coding, splice sites, and 5' and 3' untranslated regions. The pathogenicity of possible disease-causing variants was evaluated using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carboxylic Ester Hydrolases
Share to Chromosomes, Human, Pair 2

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Linkage

Share to Glycoproteins

Share to Intracellular Signaling Peptides and Proteins

Share to Lod Score

Share to Mitochondrial Proteins

Share to Osteoarthritis

Source

Identifiers

PMID: 17406639
DOI: 10.1038/sj.ejhg.5201829

Genes

IDH1
NRP2
ADAM23
FRZB

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation analysis of candidate genes within the 2q33.3 linkage area for familial early-onset generalised osteoarthritis.PMID 17406639Read ↗

Strong linkage on 2q33.3 to familial early-onset generalized osteoarthritis and a consideration of two positional candidate genes.Semantic proximity Read ↗

Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study.Semantic proximity Read ↗

The genetic epidemiology of human primary osteoarthritis: current statusSemantic proximity Read ↗

Clinical and Molecular Spectrum of Nonsyndromic Early-Onset Osteoarthritis.Semantic proximity Read ↗

Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females.Semantic proximity Read ↗

Targeted re-sequencing of linkage region on 2q21 identifies a novel functional variant for hip and knee osteoarthritis.Semantic proximity Read ↗

Genetic Determinism of Primary Early-Onset Osteoarthritis.Semantic proximity Read ↗

Genetic epidemiology of primary osteoarthritisSemantic proximity Read ↗

Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22.Semantic proximity Read ↗

Investigation of a family affected by early-onset osteoarthritis - proposal of a clinical pathway and bioinformatics pipeline for the investigation of cases of familial OA.Semantic proximity Read ↗

Association study of candidate genes for the prevalence and progression of knee osteoarthritis.Semantic proximity Read ↗

The genetics and functional analysis of primary osteoarthritis susceptibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.