Article
Strong linkage on 2q33.3 to familial early-onset generalized osteoarthritis and a consideration of two positional candidate genes.
European journal of human genetics : EJHG - 1 Dec 2006
Meulenbelt Ingrid, Min Josine L, van Duijn Cornelia M, Kloppenburg Margreet, Breedveld Ferdinand C, Slagboom P Eline
Abstract excerpt
A genomewide screen was performed in four extended families with early-onset generalized osteoarthritis (FOA) without dysplasia. The FOA phenotype within these families shows a dominant Mendelian inheritance pattern and may represent common osteoarthritis (OA) at later ages. An initial locus was confirmed by three additional families and refined by 14 markers to a two-point logarithm of odds score of 6.05...
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