Article
Nanos downregulates transcription and modulates CTD phosphorylation in the soma of early Drosophila embryos.
Mechanisms of development - 1 May 2005
Deshpande Girish, Calhoun Gretchen, Jinks Timothy M, Polydorides Alexandros D, Schedl Paul
Abstract excerpt
nanos (nos) specifies posterior development in the Drosophila embryo by repressing the translation of maternal hb mRNA. In addition to this somatic function, nos is required in the germline progenitors, the pole cells, to establish transcriptional quiescence. We have previously reported that nos is required to keep the Sex-lethal establishment promoter, Sxl-Pe, off in the germline of both sexes. We show here that...
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