Translational regulation of oskar mRNA by bruno, an ovarian RNA-binding protein, is essential.

doi:10.1016/0092-8674(95)90393-3

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Article

Translational regulation of oskar mRNA by bruno, an ovarian RNA-binding protein, is essential.

Cell - 5 May 1995

Kim-Ha J, Kerr K, Macdonald P M

Abstract excerpt

Oskar (osk) protein directs the deployment of nanos (nos), the posterior body-patterning morphogen in Drosophila. To avoid inappropriate activation of nos, osk activity must appear only at the posterior pole of the oocyte, where the osk mRNA becomes localized during oogenesis. Here, we show that translation of osk mRNA is, and must be, repressed prior to its localization; absence of repression allows osk protein...

Topics

Animals
Base Sequence
Binding Sites
Cell Compartmentation
Drosophila Proteins
Drosophila melanogaster
Egg Proteins
Embryology
Female
Gene Expression Regulation
Insect Hormones
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oocytes

Ovary

Protein Binding

Protein Biosynthesis

Proteins

Source

Open in PubMed

Identifiers

PMID: 7736592
DOI: 10.1016/0092-8674(95)90393-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7736592-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Translational regulation of oskar mRNA by bruno, an ovarian RNA-binding protein, is essential.PMID 7736592Read ↗

Two distinct domains of Bruno bind specifically to the oskar mRNA.Semantic proximity Read ↗

Translational repressor bruno plays multiple roles in development and is widely conserved.Semantic proximity Read ↗

A late phase of Oskar accumulation is crucial for posterior patterning of the Drosophila embryo, and is blocked by ectopic expression of Bruno.Semantic proximity Read ↗

Region-specific activation of oskar mRNA translation by inhibition of Bruno-mediated repression.Semantic proximity Read ↗

oskar RNA plays multiple noncoding roles to support oogenesis and maintain integrity of the germline/soma distinction.Semantic proximity Read ↗

Apontic binds the translational repressor Bruno and is implicated in regulation of oskar mRNA translation.Semantic proximity Read ↗

Drosophila cup is an eIF4E binding protein that associates with Bruno and regulates oskar mRNA translation in oogenesis.Semantic proximity Read ↗

BREs mediate both repression and activation of oskar mRNA translation and act in trans.Semantic proximity Read ↗

Multiple cis-acting signals, some weak by necessity, collectively direct robust transport of oskar mRNA to the oocyte.Semantic proximity Read ↗

RNA sequences required for the noncoding function of oskar RNA also mediate regulation of Oskar protein expression by Bicoid Stability Factor.Semantic proximity Read ↗

Premature translation of oskar in oocytes lacking the RNA-binding protein bicaudal-C.Semantic proximity Read ↗

Multiple RNA regulatory elements mediate distinct steps in localization of oskar mRNA.Semantic proximity Read ↗

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