Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BREs mediate both repression and activation of oskar mRNA translation and act in trans.

Developmental cell - 16 Mar 2010

Reveal Brad, Yan Nan, Snee Mark J, Pai Chin-I, Gim Youme, Macdonald Paul M

Abstract excerpt

Asymmetric positioning of proteins within cells is crucial for cell polarization and function. Deployment of Oskar protein at the posterior pole of the Drosophila oocyte relies on localization of the oskar mRNA, repression of its translation prior to localization, and finally activation of translation. Translational repression is mediated by BREs, regulatory elements positioned in two clusters near both ends of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to Animals, Genetically Modified

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Polarity

Share to Genes, Insect

Share to Oocytes

Share to Protein Biosynthesis

Share to Regulatory Elements, Transcriptional

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 20230756
DOI: 10.1016/j.devcel.2009.12.021
PMCID: PMC2841435

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BREs mediate both repression and activation of oskar mRNA translation and act in trans.PMID 20230756Read ↗

Two distinct domains of Bruno bind specifically to the oskar mRNA.Semantic proximity Read ↗

Multiple RNA regulatory elements mediate distinct steps in localization of oskar mRNA.Semantic proximity Read ↗

Multiple cis-acting signals, some weak by necessity, collectively direct robust transport of oskar mRNA to the oocyte.Semantic proximity Read ↗

Translational regulation of oskar mRNA by bruno, an ovarian RNA-binding protein, is essential.Semantic proximity Read ↗

Drosophila PTB promotes formation of high-order RNP particles and represses oskar translation.Semantic proximity Read ↗

Apontic binds the translational repressor Bruno and is implicated in regulation of oskar mRNA translation.Semantic proximity Read ↗

Barentsz is essential for the posterior localization of oskar mRNA and colocalizes with it to the posterior pole.Semantic proximity Read ↗

Region-specific activation of oskar mRNA translation by inhibition of Bruno-mediated repression.Semantic proximity Read ↗

Orb and a long poly(A) tail are required for efficient oskar translation at the posterior pole of the Drosophila oocyte.Semantic proximity Read ↗

RNA sequences required for the noncoding function of oskar RNA also mediate regulation of Oskar protein expression by Bicoid Stability Factor.Semantic proximity Read ↗

A late phase of Oskar accumulation is crucial for posterior patterning of the Drosophila embryo, and is blocked by ectopic expression of Bruno.Semantic proximity Read ↗

Sequential regulation of maternal mRNAs through a conserved cis-acting element in their 3’UTRsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.