Article
Association of apolipoprotein E epsilon2 and vasculopathy in cerebral amyloid angiopathy.
Neurology - 1 Apr 1998
Greenberg S M, Vonsattel J P, Segal A Z, Chiu R I, Clatworthy A E, Liao A, Hyman B T, Rebeck G W
Abstract excerpt
OBJECTIVE: Hemorrhage related to cerebral amyloid angiopathy (CAA) appears to occur through a multistep pathway that includes deposition of beta-amyloid in cerebral vessels and specific vasculopathic changes in the amyloid-laden vessels, such as cracking of the vessel wall. Recent reports suggest a positive association between CAA-related hemorrhage and both the apolipoprotein E (APOE) epsilon4 allele and,...
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