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Article

Role for glycogen synthase kinase-3 in NK cell cytotoxicity and X-linked lymphoproliferative disease.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2005

Aoukaty Ala, Tan Rusung

Abstract excerpt

NK cells from individuals with X-linked lymphoproliferative (XLP) disease exhibit functional defects when stimulated through the NK receptor, 2B4 (CD244). These defects are likely a consequence of aberrant intracellular signaling initiated by mutations of the adaptor molecule SLAM-associated protein. In this report, we show that NK cells from individuals with XLP but not healthy individuals fail to phosphorylate...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15814676
DOI: 10.4049/jimmunol.174.8.4551

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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